Ibuprofeno Alter EFG (English)

Who would want to take it, after reading, contraindications, precautions and interactions for this medicine?

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Indications

1. Rheumatoid arthritis (including juvenile rheumatoid arthritis).
2. Ankylosing spondylitis.
3. Rheumatic arthritis and other acute or chronic processes
4. Traumatic musculoskeletal pain and inflammation
5. Tto. symptomatic mild to moderate pain (pain of dental origin, postoperative pain, headache).
6. Primary dysmenorrhea.
7. Febrile
   
   

Mechanism of action

Inhibition of prostaglandin synthesis in the level periphery.

Psologia

1. Painful process of mild-moderate febrile illness: 200-400 mg/4-6 mg/6-8 h or 400 h, max. 1,200 mg / day or 600 mg/6-8 h, max. 2,400 mg / day.
2. Rheumatoid Arthritis: 1200-1800 mg / day Maintenance: 800-1200 mg / day, max. 2,400 mg / day.
3. Dysmenorrhea 1aria: 400 mg to pain relief, max. 1,200 mg / day.
4. Prolonged release hard capsule 300: 600 mg / 2 times daily in acute: 900 mg / 2 times a day, maintenance: 300-600 mg / 2 times a day.
5. Compressed retard 600: 600 mg/12 h; Maintenance: 600-1200 mg / day.
6. Extended-release tablet 800: ads. and children from 12 years: 1,600 mg / day (single dose). In serious or acute: 2,400 mg / day (800 mg / 1,600 mg morning / afternoon).
7. Children: 20-30 mg / kg / day in 3-4 divided doses. Juvenile rheumatoid arthritis: max. 40 mg / kg / day.
8. Rectal. Ads.: 500 mg / 4 h. Children: given from 3 months of age (6.0 kg bw). The maximum total daily dose. 20-30 mg / kg / day, max. 3 days.
    
   

Contraindications

1. Hypersensitivity to ibuprofen  
2. Previous history of allergic reaction
3. Patients who have or have had asthma, rhinitis, urticaria, nasal polyps, angioedema, history of gastrointestinal bleeding
4. Inflammatory bowel, severe renal dysfunction, severe hepatic dysfunction.
5. Bleeding diathesis or other bleeding disorders. - Third trimester of pregnancy
   
   

Precautions

1. I.H. mild to moderate (reduce initial dose).
2. I.R. mild to moderate (reduce initial dose
3. Elders
4. Children with severe dehydration
5. Ulcerative colitis.
6. Crohn's disease
7. Hypertension and / or insuf. heart
8. Bronchial asthma
9. Hematopoietic Disorders
10. Systemic lupus erythematosus or enf. Mixed connective tissue
11. Risk of gastrointestinal bleeding
12. Ulceration or perforation is higher with increasing NSAID doses, in patients with a history of ulcer and elderly.
13. HTA.
14. ICC
15. Enf. established coronary artery.
16. Peripheral artery disease and / or enf. stroke.
17. Acute intermittent porphyria
18. Cardiovascular risk factors (Hypertension, hyperlipidemia, diabetes mellitus, smoking)

It can mask symptoms of infection (avoid if chickenpox). Control to undergoing major surgery. Control renal, hepatic and hematologic. Risk of skin reactions at the start of tto. You can alter female fertility. Rectal: alteration of the rectum or anus.

Ibuprofen and its metabolites pass at low concentrations into breast milk. So far there are no known harmful effects on children, which is generally not necessary to interrupt breast feeding for a short treatment with the recommended dose for pain and fever.
Patients who experience dizziness, vertigo, visual disturbances or other central nervous system disorders while taking ibuprofen should not drive or operate machinery. If given a single dose of ibuprofen for a short period is not necessary precautions.

Interactions

1. Reduces efficacy of furosemide, thiazide diuretics
2. Reduces efficacy of furosemide, thiazide diuretics.
3. Reduce effect of mifepristone
4. Increased plasma levels of: digoxin, phenytoin and lithium
5. Increases toxicity of methotrexate, hydantoins, sulfonamides
6. Power gastrointestinal lesions: salicylates, phenylbutazone, indomethacin.
7. Increases effect of: oral hypoglycemic agents and insulin
8. Additive effect on platelet inhibition, ticlopidine
9. Increased risk of hematotoxicity with: zidovudine
10. Power bleeding time: anticoagulants
11. Increased risk of nephrotoxicity, tacrolimus, cyclosporine
12. Increased risk of gastrointestinal bleeding and ulceration 
13.